Título: "A review of salivary gland histopathology in primary Sjögren’s syndrome with a focus on its potential as a clinical trials biomarker"
Autores: Benjamin A Fisher, Rachel M Brown,
Simon J Bowman, Francesca Barone.
Fisher BA, Brown RM, Bowman SJ, et al .
Ann Rheum Dis 2015; 74 :1645 – 1650.
Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important role in the diagnosis of primary Sjögren’s syndrome (PSS) and were fi rst described over 40 years ago. Recent evidence suggests that minor salivary gland biopsy may also provide information useful for prognostication and strati fi cation, yet dif fi culties may arise in the histopathological interpretation and scoring, and evidence exists that reporting is variable. With the increasing number of actual and proposed clinical trials in PSS, we review the evidence that might support the role of histopathology as a biomarker for strati fi cation and response to therapy and highlight areas where further validation work is required.